Our Resources
Professor Anthony Moore
Relevant Publications (from 2013)
1. Copsey, A.C., Barsottini, M.R.O., May, B., Xu, F., Albury, M.S., Young, L. and Moore, A.L. (2021) Nature Scientific Reports In Press. “Kinetic characterisation and inhibitor sensitivity of Candida albicans and Candida auris recombinant AOX expressed in a self-assembled proteoliposome system”
2. Rubbiani, R., Weil, T., Tocci, N., Mastrobuoni, L., Jeger, S., Moretto, M., Ng, J., Lin, Y., Hess, J., Ferrari, S., Kaech, A., Young, L., Spencer J., Moore, A.L., Cariou, K., Borghi, M., Giorgia, R., Romani, L. and Gasser, G. (2021) RSC Chem. Biol In Press “in vivo Active Organometallic-containing Antimycotic Agents”
3. Yamasaki, S., Shoji, M., Kayanuma, M., Sladek, V., Inaoka, D.K., Matsuo, Y., Shiba, T., Young, L., Moore, A.L., Kita, K. and Shigeta, Y. (2021) Biochim Biophys Acta 1862 148356 doi.org/10.1016/j.bbabio.2020.148356 “Weak O2 binding and strong H2O2 binding at the non-heme diiron center of Trypanosome Alternative Oxidase”
4. Rosell-Hidalgo, A., Young, L., Moore, A.L. and Ghafourian T. (2020) J. Computer Aided Molecular Design. doi: 10.1007/s10822-020-00360-8. “QSAR and molecular docking for the search of AOX inhibitors: a rational drug discovery approach”
5. Ito, K., Ogata, T., Seito, T., Umekawa, Y., Kakizaki, Y., Osada, H., and Moore, A.L. (2020) Biochem J. 477, 3417-3431 “Degradation of mitochondrial alternative oxidase in the appendices of Arum maculatum”
6. Young, L., Rosell-Hidalgo, A., Inaoka, D.K., Xu, F., Albury, M., May, B., Kita, K. and Moore, A.L. (2020) Biochim Biophys Acta 1861, 148247 “Kinetic and structural characterisation of the ubiquinol-binding site and oxygen reduction by the trypanosomal alternative oxidase.”
7. Barsottini, M.R.O., Copsey,, A., Young, L., Baroni, R.M., Cordeiro, A.T., Pereira, G.A.G. and Moore, A.L. (2020) Nature Communications Biology DOI: 10.1038/s42003-020-0981-6 “Biochemical characterization and inhibition of the alternative oxidase enzyme from the fungal phytopathogen Moniliophthora perniciosa”
8. Szibor, M., Viscomi, C., Fernandez-Vizarra, E., Gizatullina, Z., Vielhaber, S., Debska-Vielhaber, G., Gainutdinow, T., Heidler, J., Dufour, E., Wittig, I., Gellerich, F. and Moore, A.L. (2020) Biochim. Biophys. Acta 1861, 148137 doi.org/10.1016/j.bbabio.2019.148137. “The bioenergetic consequences of AOX expression in mammalian mitochondria: Effect upon FET, RET & ROS”
9. Balogun, E.O., Inaoka, D.K., Shiba, T., Tsuge, C., May, B., Sato, T., Kido, Y., Nara, T., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, S., Michels, P.A.M., Watanabe, Y., Moore, A.L., Harada, S. and Kita, K. (2019) FASEB J. 33, 13002-13013. “Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase of Trypanosoma brucei brucei”
10. Shiba, T., Inaoka, D.K., Takahashi, G., Tsuge, C., Kido, Y., Young, L., Ueda, S., Balogun, E.O., Nara, T., Honma, T., Tanaka, A., Inoue, M., Saimoto, H., Harada, S., Moore, A.L. and Kita, K. (2019) Biochim. Biophys. Acta 1860 375-382. “Insights into the ubiquinol/dioxygen binding and proton relay pathways of the alternative oxidase”.
11. Tsaousis, A. D., Hamblin, K. A., Elliot, C., Young, L., Hidalgo-Rosell A., Gourlay C. W., Moore, A. L. & van der Giezen, M. (2018) Front. Cell. Infect. Microbiol., 8 371-382 “The human gut colonizer Blastocystis respires using Complex II and alternative oxidase to buffer transient oxygen fluctuations in the gut”
12. Miyazaki, Y., Inaoka, D. K., Shiba, T., Saimoto, H., Sakura T., Amallia, E., Kido, Y., Sakai, C., Nakamura, M., Moore, A. L., Harada, S. & Kita, K. (2018) Frontiers in Pharmacology, Pharmacology of Anti-Cancer Drugs. 9, 1-13 “Selective cytotoxicity of dihydroorotate dehydrogenase inhibitors to human cancer cells under hypoxia and nutrient-deprived conditions”
13. May, B., Young, L. & Moore, A.L. (2017) Biochem. Soc. Trans. 45, 731-740. “Structural insights into the alternative oxidases: are all oxidases made equal?”
14. Jones, A.J.Y., Blaza, J.N., Bridges, H.R., May B., Moore A.L., and Hirst, J. (2016) Angew. Chem. Int. Ed. 55, 728 –731 “A Self-Assembled Respiratory Chain that Catalyzes NADH Oxidation by Ubiquinone-10 Cycling between Complex I and the Alternative Oxidase”.
15. Young, L., Inaoka, D., Shiba, T., Harada, S., Kita, K., Albury, M.S. & Moore, A. L. (2016) In Cytochromes and Cytochrome Complexes (eds. Kallas, T. & Cramer, W.), Advances in Photosynthesis and Respiration Series (Series Editors, Govindjee and Sharkey) Springer. pp 375-394. “Structure and mechanism of action of the alternative quinol oxidases”
16. May B., Elliott C., Iwata, M., Young L., Shearman J., Albury M.S. and Moore A.L. (2015) In "Methods in Molecular Biology – Plant Mitochondria" (J. Whelan, ed.). Humana Press, New Jersey. pp 281-299. “Expression and Crystallisation of the plant alternative oxidase”
17. Elliott, C., Albury, M.S., Young, L., May, B. & Moore A.L. (2015) In ‘Alternative Respiratory Pathways in Higher Plants’ (Eds Gupta, K.J., Mure, L.A.J. & Neelwarne, B.) John Wiley & Sons, Oxford. pp75-93 “Structural elucidation of the alternative oxidase reveals insights into the catalytic cycle and regulation of activity
18. Elliott C., Young L., May B., Shearman J., Albury M.S., Kido, Y, Kita K. and Moore A.L. (2014) Mitochondrion 19, 261-268 “Purification and characterisation of recombinant DNA encoding the alternative oxidase from Sauromatum guttatum”
19. Young L., May B., Pendlebury-Watt A., Shearman J., Elliott C., Albury M.S., Shiba T., Inaoka D.K., Harada S., Kita K. and Moore A.L. (2014) Biochim.Biophys. Acta 1837, 1229-1235 "Probing the ubiquinol-binding site of recombinant Sauromatum guttatum alternative oxidase expressed in E. coli membranes through site-directed mutagenesis."
20. Young, L., Shiba, T., Harada, S., Kita, K., Albury, M.S. & Moore, A. L. (2013) Biochem. Soc. Trans. 41, 1305-1311 “The alternative oxidases: simple oxidoreductase proteins with complex functions”
21. Moore, A. L., Shiba, T. Young, L. Harada, S., Kita, K. & Ito K. (2013) Annu Rev. Plant Biol. 64, 637-663 “Unraveling the heater: New insights into the structure of the alternative oxidase”
22. Shiba, T., Kido, Y., Inaoka, D. K., Balogun, E. O., Sakamoto, K., Nara, T., Aoki, T., Honma, T., Tanaka, A., Inoue, M., Matsuoka, S., Saimoto, H., Moore, A., Harada, S. & Kita, K. (2013) Proc. Natl. Acad. Sci. (USA) 110, 4580-85. “The structure of the trypanosomal cyanide-insensitive alternative oxidase”